This one is extremely easy. The big metal ball guy in the Incredibles game. And not even late in the game, just when he's in the volcano. I never ****ing beat that guy. Damn you Disney, making challenging games =P
The monkeys in Time Splitters, i hated having to aim down to kill them. They became my main enemy in that game.
Ganondorf,merely becuase in my mind Ocarina of Time is still the **** as far a videogames go. Mind you Glados is definately up there
QFT Ganondorf will always take the cake for me, since I grew up with Zelda (iv'e played them all). However, I also think President Eden deserves an hounerable mention, along with Glados and some others. As far as hardness, the Final four in pokemon, those motherfuckers wont die!
RAAM in Gears of War 1 is definitely WAAAY harder. Skorge is doing it right, and RAAM is a test of how good you are at staying alive.
I'm not really a huge gamer, so i don't know the names of many of the bad guys... Prophet of Truth? Dr Neo Cortex from Crash Bandicoot 2 onwards? I'm bad at this...
Pokemon? I'm sorry, but you're an uber noob. Seriously, the Final Four are so easy. I always go in when I've gotten them all to at least level 80. Except for some. I take some in at level 50.